Midland Main Line Layers
- Class 158/0 EMT
- Class 43 EMT
- Class 66 (requires East Coastway or Southeastern High Speed)
- Class 45/1 (requires Northern Transpennine)
- Class 47/4 (Scenery only, requires Blackpool Branches)
- Class 37/7 EPX (Requires Rail Operations Group Class 37))
- LMS Jubilee (requires Spirit of Steam)
- Class 31 (Scenery only, requires Tees Valley Line)
- Flying Scotsman (requires Flying Scotsman add-on)
- Class 08 (Scenery only, requires Blackpool Branches)
- Cargo Line Petroleum (DLC)
- Cargo Line Aggregates (DLC)